SubjectsHuman Body FactsFactsIP FactoidsRecord Breaking Facts Tooth enamel is the hardest substance in the human body. By IP Factly - Nov 10, 2016 0 4 Share on Facebook Tweet on Twitter Image credit: Otis Historical Archives Nat'l Museum of Health & Medicine/CC BY 2.0 Image credit: Otis Historical Archives Nat’l Museum of Health & Medicine/CC BY 2.0 The white part of your tooth is harder than anything else in your body, even your hardest bone, made up of 96% mineral. In spite of this, though, it still decays when continually exposed to acids and sugars.